George Cremaschi was born in New York City, and studied music and composition there. He has played with, and composed for, dancers, rock bands, installation artists, improvisers, poets, film, folk musicians, theater groups, orchestras, and pop divas. He has worked with a long list of fantastic artists: Greg Goodman, Saadet Türköz, Matthew Ostrowski, Nicolas Collins, Evan Parker, Trinh T. Minh-Ha, Liz Allbee, Burkhard Stangl, Mats Gustafsson, Kai Fagaschinski, Lę Quan Ninh, Gino Robair, Rova Saxophone Quartet, Frédéric Blondy, Christof Kurzmann, Nels Cline, Andrea Parkins, Paul Lovens, Marshall Allen, Han Bennink, Butch Morris, and many others.

As an interpreter, he has performed works by Morton Feldman, James Tenney, John Cage, Iannis Xenakis, Cornelius Cardew, Roscoe Mitchell, Christian Wolff, Wadada Leo Smith, Krzysztof Penderecki, Jon Raskin, Ana-Maria Avram, Louis Andriessen and Matthew Goodheart among many others.

He has appeared on over 30 recordings on the Apestaartje, Evolving Ear, Black Saint, Leo, Beak Doctor, Emanem, Rastascan, Music & Arts, Nine Winds and 482 Music labels.